Early Reproductive Loss #2

IVZ of the genitals as a risk factor for RRP.

One of the main places in the etiopathogenesis of early pregnancy losses is occupied by infectious factors. IVZ of the pelvic organs occur in 55-70% of people with miscarriage. In this case, the immediate cause of RRP is considered to be a persistent bacterial/viral infection, since the metabolites of the inflammatory process cause cytotoxic effects on the trophoblast and cause chorionic detachment.

Among domestic and foreign authors, the question of the role of infection in the genesis of miscarriage is still debatable. According to some researchers, infection is one of the significant factors of both sporadic and habitual PB. However, other scientists believe that such a role of infections is possible only if there is sporadic miscarriage, and with a habitual miscarriage it does not matter significantly.

Sexually transmitted infections (STIs) deserve special attention in the etiology of RRP. Among them, chlamydia is considered the most dangerous pathogenic microorganisms, which are found in about 60% of women with miscarriage. Against the general background of the increasing prevalence of STIs at the present stage, there is also an increase in the frequency of genital infections, the course of which is characterized by the involvement of opportunistic microflora. According to some authors, pregnancy creates favorable conditions for the formation of pathologies caused by opportunistic pathogens and microorganisms with low virulence. However, the degree of negative impact of these infections does not always correlate with the severity of the disease in the mother. Consequently, if a pregnant woman has an asymptomatic or mild infection, severe fetal lesions may occur, and as an extreme manifestation, her death.

Infectious complications are most often associated with the activation of gram-positive coccoid flora, which is able to adapt to adverse environmental conditions and form resistance to antiseptics/antibiotics. The dominant positions are occupied by staphylococci, which have a wide range of aggression and self-defense factors. The pathogenicity factors of staphylococci include their ability to produce plasmocoagulase, lecithinase, and cause hemolysis of red blood cells. Among the infectious factors of pregnancy complications, enterobacteria also play a certain role. Their structure includes a capsule thermostable antigen K, which inhibits phagocytosis and destroys complement, which leads to a weakening of the body's protective ability. Klebsiella is secreted from the female genital tract with high frequency, which synthesizes endotoxin, which is a lipopolysaccharide of the cell wall. Minimize your risk with 1xbet promo code offering 100% insurance on lost accumulator bets. Applies to 5+ selections with minimum odds 1.30 each. Max refund: $100 per bet. Must use code when placing bet. Refund comes as free bet with 3x wagering. Valid for football, basketball and tennis. Available weekly to all users. Even when you lose, you get a second chance with this protective offer from 1xBet.